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MolecularImagingofImmuneCellDynamicsDuringDe-andRemyelinationintheCuprizoneModelofMultipleSclerosisby[18F]DPA-PETandMRI
Abstract
Background:Activationanddysregulationofinnate,adaptiveandresidentimmunecellsinresponsetodamagedeterminethepathophysiologyofdemyelinatingdisorders.Amongtheplethoraofinvolvedcells,microglia/macrophagesandastrocytesplayanimportantroleinthepathogenesisofdemyelinatingdisorders.Thein-depthinvestigationofthespatio-temporalprofileofthesecelltypesinvivomayinformabouttheexactdiseasestateandlocalizationaswellasmayallowtomonitortherapeuticmodulationofthe
