Berzosertibplusgemcitabineversusgemcitabinealoneinplatinumresistanthighgradeserousovariancancer:amulticentre,openlabel,randomised,phase2trial.
Berzosertib+吉西他滨vs吉西他滨单药治疗铂耐药的高级别浆液性卵巢癌：一项多中心、开放标签、随机、2期试验。
KonstantinopoulosPA,etal.LancetOncol.;21(7):.doi:10./S(20).
Abstract
摘要
BACKGROUND
Highgradeserousovariancancersshowincreasedreplicationstress,renderingcellsvulnerabletoATRinhibitionbecauseofnearuniversallossoftheG1/Scheckpoint(throughdeleteriousTP53mutations),prematureSphaseentry(duetoCCNE1amplification,RB1loss,orCDKN2AmRNAdownregulation),alterationsofhomologousre